Cognitive consequences of high Aß amyloid in mild cognitive impairment and healthy older adults: Implications for early detection of Alzheimer�s disease.Artículo de Revista
It has been proposed that only mild cognitive impairment (MCI) with high Aß amyloid is indicative of incipient Alzheimer¿s disease (AD), yet MCI with low Aß amyloid may reflect other neurodegenerative processes. We aimed to determine the extent to which high Aß amyloid influenced cognitive function in healthy older adults and adults with MCI. Method: Healthy controls (HC; n = 178) and adults with MCI (n = 56) enrolled in the Australian Imaging, Biomarkers, and Lifestyle study, underwent positron emission tomography neuroimaging for Aß amyloid and completed an extensive neuropsychological battery, assessing the cognitive domains of verbal and visual episodic memory, executive function, visuoconstruction, attention and processing speed, and language at baseline. Results: MCI with low Aß performed worse than MCI with high Aß on measures of executive function, attention, visuoconstruction and language. No differences were observed between HC high and low Aß groups. When compared with HC with low Aß, both MCI high and low Aß groups performed worse on measures of episodic memory. However, only the MCI low Aß group performed worse than HC low Aß on measures of executive function, attention, visuoconstruction, and language. Conclusions: When compared with HC with low Aß amyloid, MCI with high Aß amyloid present with impairments restricted to episodic memory, and the episodic memory impairments in MCI with low Aß amyloid were accompanied by impairments in executive function, attention, visuoconstruction, and language, suggesting that MCI with high Aß amyloid reflects prodromal AD, although further longitudinal data is required to confirm this. (PsycINFO Database Record (c) 2013 APA, all rights reserved)
