Mnemonic strategy trainig improves memory for object location associations in both healthy elderly and patients with amnestic mild cognitive impairment: A randomized, single-blind study. Artículo de Revista
Autores: Benjamin M. Hampstead; Krish Sathian; Pamela A. Philips; Akshay Amareneni; William R. Delaune; Anthoony Y. Stringer.
Resumen
Objective: To evalute the efficacy of mnemonic strategy trainig versus a matched-exposure control condition and to examine the relationship between training-related gains, neuropsychological abilites, and medial temporal lobe volumetrics in patients with amnestic mild cognitive impairment (aMCI) and age-matched heatly controls. Method: Twenty-three of 45 screened heatly controls and 29 of 42 screened patients with aMCI were randomized to nmemonic strategy of matched-exposure groups. Groups were run in parallel, with participants blind to the other intervention. All participants completed five sesions within 2 weeks. Memory testing for object location association (OLAs) was performed during sessione one and five and at a 1-month follow-up. During sessiones 2-4, participants received either mnemonic strategy trainig or a matched number of exposures with corrective feedback for a total of 45 OLAs. Structural magnetic resononce imaginig was performed in most participants and medial temporal lobe volumetrics were acquired. results: twenty-one heatly controls and 28 patients with aMCI were included in data analysis. Mnemonic strategy training was significatly more beneficial than matched exposure immediately after training p=006, partisl n2=16, and at 1 month p <001, partial n2 =35, regardless of diagnostic group. Although patients with aMCI demonstrated gains comparable to the heatly control groups, their overall performace generally remained reduced. Nmemonic strategy-related improvement was correlated positivety wuth baseline memory and executive funcitioning and negatively with inferior lateral ventricle volume un patients with aMCI; no significant relationships were evident in matched-exposure patients. Conclusion: Mnemonic strategies effectively improve memory for specific content for at least month patients with aMCI.
