Hormonal and cognitive factors associated with the expliratory behavior of rats submitted to repeated sessions of the eleveted plus-maze. Artículo de Revista
Autores: Lucas Albrechet Souza; Marcus L. Brandao.
Resumen
Naive rats submitted to the elevated plus-maze (EPM) dsiplay a characteristic increase in open arm exploration and reduced risk assessment behaviors (RABs) after the administration of anxiolytic drugs. Upon re-exposure to the maze, however, the traditional mesures of the EPM become resistant to these drugs. Thisintriguing phenomenon was initially observed for the benzosiazepine chlordiazepoxide and referred as one-tiral tolerence (OTT). In this review, we summarized hormonal. cognitive and neuroanatomical data obtained from rats submitted to the test/retest protocol in the EPM. The re-exposure to the EPM is characterized by more prominent RABs and a distinct Fos protein distribution in the brain, particularly in limbic structures involveld with the cognitive aspects of fear, such as the ventral regions of the medial prefrontal cortex (mPFC) and amygdala.
