James H. MacCabe; Gildas Brebion; Abraham Rechenberg; Taposhri Ganguly; Peter J. McKenna.
Resumen
Objective. It has been suggested that neurocognitive impairment is a core deficit in schizoprenia. However, it appear that some patients with schizopherenia have intelligence quotients (IQs) in the superior range. In this sutdy, we sougth out schizophrenia patients with an estimated premorbid Intelligence Quotient (IQ) of a least 115 and studied their neuropsuchological profile. Method: Thirty-four patients meeting diagnostic criteria for schizophrenia or schizoaffective disorder, as defined by the Diagnostic and Statistical Manual of mental Disords (4th ed; DSM-IV), with mean estimated premorbid IQ of 120, were recrutied and divided into two subgroups,a ccording to wethere or not their IQ had declined by al least 10 points from their premorbid estimate. Their perfromance on an extensive neuropsychological battery was compared with that of 19 IQ-matched healtly controls and a group of 16 "typical" chizophrenia patients with estimated premorbid IQ <110, using one way ANOVAs and profile analysis using MANOVAs.
